Polynucleotides face
Polynucleotides represent a significant advancement in regenerative aesthetic medicine. This injectable treatment utilizes highly purified DNA fractions, typically derived from freshwater fish, to stimulate your skin cells to repair and regenerate from within.
Unlike traditional dermal fillers that simply add physical volume, polynucleotides work to fundamentally improve the overall health and structural integrity of your skin. Once injected, they signal your body’s fibroblasts to increase natural collagen and elastin production while simultaneously providing deep hydration and reducing cellular inflammation.
- Cellular Repair: Promotes natural tissue regeneration for a healthier, more resilient skin barrier.
- Deep Hydration: Binds to water molecules to significantly improve skin moisture retention for a natural glow.
- Collagen Stimulation: Encourages the sustained production of collagen and elastin to soften fine lines and improve skin elasticity.
- Reduced Redness: Calms underlying inflammation, making it an excellent option for managing conditions like rosacea or general skin sensitivity.
To ensure a safe and effective procedure, please arrive at the clinic completely makeup-free with a clean face.
Upon your arrival, your clinician will thoroughly cleanse your skin. Depending on your preference and treatment plan, we may apply a topical anesthetic cream prior to the procedure to maximize your comfort. Once the skin is fully prepared, the polynucleotide gel is carefully injected into the targeted areas of your face using a very fine needle or a micro-cannula. The entire process is controlled and customized to address your specific aesthetic concerns.
Immediately after the treatment, it is completely normal to experience small raised bumps or blebs at the injection sites, along with mild redness or swelling. These localized reactions typically resolve on their own within 24 to 48 hours.
- The First 24 Hours: Please do not touch, massage, or rub your face. You must avoid applying any makeup or active skincare products to the treated area to prevent infection.
- Heat & Exertion: Avoid intensive cardiovascular exercise, saunas, steam rooms, and hot showers for 24 hours following your appointment.
- Sun Protection: Apply a daily broad-spectrum SPF 50 to protect your skin from UV exposure as it heals and regenerates.
Because this treatment relies on biological cellular turnover, the changes are gradual and natural. While you may notice an initial improvement in hydration, maximal and optimum results will become visible 3 to 4 weeks after your final session in the treatment course, as the new collagen and elastin networks are fully established.
Our Elite Polynucleotide option uses Rejuran, one of the most recognised premium polynucleotide treatments in Korean aesthetic medicine.
Like our Signature tier, Rejuran works by supporting the skin’s natural repair processes rather than adding volume or changing facial structure. It is designed to improve overall skin quality, helping with concerns such as fine lines, crepey texture, reduced elasticity, dullness and tired-looking skin.
Where Rejuran stands apart is in its reputation as a highly refined, premium regenerative skin treatment. It is particularly well suited to patients who want a more advanced skin-quality treatment, especially in delicate areas such as the under-eyes, or for those wanting a more elevated approach to collagen support, repair and long-term skin resilience.
Our Signature Plinest tier remains an excellent medical-grade polynucleotide option and is suitable for many patients starting their regenerative skin journey. Our Elite Rejuran tier is for those who want to take this a step further with a premium Korean polynucleotide treatment, chosen for its strong reputation in skin healing, texture refinement and natural-looking rejuvenation.
Polynucleotides face
Polynucleotides represent a significant advancement in regenerative aesthetic medicine. This injectable treatment utilizes highly purified DNA fractions, typically derived from freshwater fish, to stimulate your skin cells to repair and regenerate from within.
Unlike traditional dermal fillers that simply add physical volume, polynucleotides work to fundamentally improve the overall health and structural integrity of your skin. Once injected, they signal your body’s fibroblasts to increase natural collagen and elastin production while simultaneously providing deep hydration and reducing cellular inflammation.
- Cellular Repair: Promotes natural tissue regeneration for a healthier, more resilient skin barrier.
- Deep Hydration: Binds to water molecules to significantly improve skin moisture retention for a natural glow.
- Collagen Stimulation: Encourages the sustained production of collagen and elastin to soften fine lines and improve skin elasticity.
- Reduced Redness: Calms underlying inflammation, making it an excellent option for managing conditions like rosacea or general skin sensitivity.
To ensure a safe and effective procedure, please arrive at the clinic completely makeup-free with a clean face.
Upon your arrival, your clinician will thoroughly cleanse your skin. Depending on your preference and treatment plan, we may apply a topical anesthetic cream prior to the procedure to maximize your comfort. Once the skin is fully prepared, the polynucleotide gel is carefully injected into the targeted areas of your face using a very fine needle or a micro-cannula. The entire process is controlled and customized to address your specific aesthetic concerns.
Immediately after the treatment, it is completely normal to experience small raised bumps or blebs at the injection sites, along with mild redness or swelling. These localized reactions typically resolve on their own within 24 to 48 hours.
- The First 24 Hours: Please do not touch, massage, or rub your face. You must avoid applying any makeup or active skincare products to the treated area to prevent infection.
- Heat & Exertion: Avoid intensive cardiovascular exercise, saunas, steam rooms, and hot showers for 24 hours following your appointment.
- Sun Protection: Apply a daily broad-spectrum SPF 50 to protect your skin from UV exposure as it heals and regenerates.
Because this treatment relies on biological cellular turnover, the changes are gradual and natural. While you may notice an initial improvement in hydration, maximal and optimum results will become visible 3 to 4 weeks after your final session in the treatment course, as the new collagen and elastin networks are fully established.
Our Elite Polynucleotide option uses Rejuran, one of the most recognised premium polynucleotide treatments in Korean aesthetic medicine.
Like our Signature tier, Rejuran works by supporting the skin’s natural repair processes rather than adding volume or changing facial structure. It is designed to improve overall skin quality, helping with concerns such as fine lines, crepey texture, reduced elasticity, dullness and tired-looking skin.
Where Rejuran stands apart is in its reputation as a highly refined, premium regenerative skin treatment. It is particularly well suited to patients who want a more advanced skin-quality treatment, especially in delicate areas such as the under-eyes, or for those wanting a more elevated approach to collagen support, repair and long-term skin resilience.
Our Signature Plinest tier remains an excellent medical-grade polynucleotide option and is suitable for many patients starting their regenerative skin journey. Our Elite Rejuran tier is for those who want to take this a step further with a premium Korean polynucleotide treatment, chosen for its strong reputation in skin healing, texture refinement and natural-looking rejuvenation.
Frequently Asked Questions
How long do the results of face polynucleotides last?
Once your initial course of treatment is complete and the new collagen and elastin networks have fully matured, results typically last between 6 to 9 months. Because this is a true regenerative treatment that actively improves the structural health of your cells, your skin will naturally age better over time. To sustain these optimal cellular benefits, we recommend a single maintenance session every 6 months.
Do polynucleotide injections hurt?
The treatment is generally very well-tolerated. We use ultra-fine needles or micro-cannulas to administer the product, and your clinician may apply a premium topical anesthetic cream beforehand to maximize your comfort. You may feel a slight tingling or mild pressure as the bio-stimulating gel is introduced into the dermis, but this sensation is very brief and the process is highly controlled.
What is the difference between polynucleotides and dermal fillers?
Traditional dermal fillers use dense hyaluronic acid to physically add volume, contour the face, or alter underlying facial proportions. Polynucleotides are strictly regenerative and do not add physical volume or change your facial shape. Instead, they work at a cellular level to repair damaged tissue, deeply hydrate, and stimulate your own natural collagen production for a firmer, healthier, and highly authentic complexion.
Will my face look bumpy or swollen after the treatment?
Yes, it is completely normal to have small, raised bumps or “blebs” at the injection sites immediately following the procedure. This is simply the biological product resting in the superficial layers of your skin before it fully absorbs. These bumps typically integrate and flatten out entirely within 24 to 48 hours. Mild redness and localized swelling may also occur but will naturally subside within a few days.
How many polynucleotide sessions will I need?
Because polynucleotides rely on biological cellular turnover to naturally repair the skin, a single session is not sufficient to achieve clinical results. For facial rejuvenation, we recommend a primary protocol of three to four sessions, spaced three to four weeks apart. This structured medical course ensures your fibroblasts receive a consistent, powerful stimulus to successfully rebuild strong collagen and elastin networks.
What is the difference between your Signature and Elite polynucleotide treatments?
Our Signature tier uses Plinest, a high-quality medical-grade polynucleotide treatment designed to support skin repair, hydration, elasticity and overall skin quality.
Our Elite tier uses Rejuran, a premium Korean polynucleotide treatment with a strong international reputation for regenerative skin repair and natural-looking rejuvenation. It is especially suited to patients who want a more elevated option for concerns such as fine lines, crepey skin, under-eye ageing, texture changes and reduced skin resilience.
Both treatments are designed to improve skin quality gradually and naturally. The main difference is that Rejuran is positioned as our more premium regenerative option, while Plinest remains an excellent choice for patients wanting an effective and clinically trusted polynucleotide treatment.
